The prevalence and distribution of HPV types in nasal inverted papilloma in Chinese Han population

Background: Human papillomavirus (HPV) was reported as a possible etiological agent for Nasal inverted papilloma (NIP). However, the prevalence of HPV types in NIP was not well known. Materials and Methods: 102 formalin-fixed paraffin-embedded NIP biopsy samples were obtained from patients and 20 samples were got from healthy controls. HPV DNA genotyping was achieved by a flow-through hybridization and gene-chip method and genotyping of 21 different HPV types. The incidences of HBV subtype infection in patients with NIP and its distribution across age, gender and stage were described. Results: Patients with NIP had higher incidence of HPV infection (64.7%) compared with healthy control. The positive rate was higher in patients with advanced Krouse Stage and in patients more than 59 years old. HPV 11 was the mostly-seen type in patients at Krouse StageT1 and T2, and HPV 58 was found in 45.0% of patients with T3 NIP. There tends to be a difference in HPV infection rate between patients with NIP only and patients with NIP and dysplasia with no statistical significance. The most common HPV types in patients with NIP and dysplasia were HPV11 (40.8%) and HPV58 (27.6%) respectively. Conclusions: The prevalence of HPV in NIP was high (64.7%) and HPV infection was more seen in older patients and patients with advanced Krouse Stage. Different HPV type distribution was found across Krouse Stage and the degree of dysplasia.